Integrating reaction and analysis: investigation of higher-order reactions by cryogenic trapping

• Skrollan Stockinger and
• Oliver Trapp

Beilstein J. Org. Chem. 2013, 9, 1837–1842, doi:10.3762/bjoc.9.214

• Skrollan Stockinger Oliver Trapp Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany 10.3762/bjoc.9.214 Abstract A new approach for the investigation of a higher-order reaction by on-column reaction gas chromatography is

• ; cycloaddition; Diels–Alder reaction; flow chemistry; gas chromatography; on-column reaction gas chromatography; Introduction The combination of synthesis and analysis in a single experiment offers many advantages. Time-consuming steps, i.e. work-up and separation of the reaction products, can be minimized, and

• , which is discussed in the present contribution. Here, we use a focusing technique to concentrate and stop separating several substances in a single column section to study higher-order reactions and to increase the conversion in on-column reaction gas chromatography (ocRGC). The major challenge in